EFNB2

Gene Information

Official Symbol: EFNB2
Official Name: ephrin B2
Aliases and Previous Symbols: N/A
Entrez ID: 1948
UniProt: P52799
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14879
Expression level (log2 read counts): 5.4

Expression Distribution

regulation of aorta morphogenesis
positive regulation of aorta morphogenesis
regulation of artery morphogenesis
positive regulation of artery morphogenesis
venous blood vessel morphogenesis
regulation of postsynaptic neurotransmitter receptor internalization
nephric duct morphogenesis
negative regulation of keratinocyte proliferation
venous blood vessel development
nephric duct development
presynapse assembly
positive regulation of cardiac muscle cell differentiation
cell migration involved in sprouting angiogenesis
presynapse organization
lymph vessel development
ephrin receptor binding
positive regulation of cardiocyte differentiation
blood vessel endothelial cell migration
regulation of keratinocyte proliferation
regulation of cardiac muscle cell differentiation
positive regulation of cardiac muscle tissue development
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of cardiocyte differentiation
integral component of postsynaptic density membrane
regulation of receptor internalization
T cell costimulation
lymphocyte costimulation
sprouting angiogenesis
integral component of presynaptic membrane
positive regulation of striated muscle cell differentiation
endothelial cell migration
positive regulation of muscle organ development
positive regulation of striated muscle tissue development
positive regulation of muscle tissue development
virus receptor activity
regulation of cardiac muscle tissue development
Schaffer collateral - CA1 synapse
epithelial cell migration
ephrin receptor signaling pathway
epithelium migration