EGR3 [The Human Chemical-Genetic Interaction Map Project]

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======= EGR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EGR3
  * **<color #00a2e8>Official Name</color>**: early growth response 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1960|1960]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06889|Q06889]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EGR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EGR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602419|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcription factor involved in muscle spindle development.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3446|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of gamma-delta T cell differentiation|
|regulation of gamma-delta T cell activation|
|endothelial cell chemotaxis|
|positive regulation of T cell differentiation in thymus|
|cell migration involved in sprouting angiogenesis|
|regulation of T cell differentiation in thymus|
|blood vessel endothelial cell migration|
|neuromuscular synaptic transmission|
|cellular response to vascular endothelial growth factor stimulus|
|sprouting angiogenesis|
|endothelial cell migration|
|peripheral nervous system development|
|positive regulation of T cell differentiation|
|epithelial cell migration|
|epithelium migration|
|positive regulation of endothelial cell proliferation|
|positive regulation of lymphocyte differentiation|
|tissue migration|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of endothelial cell proliferation|
|regulation of T cell differentiation|
|circadian rhythm|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|ameboidal-type cell migration|
|positive regulation of hemopoiesis|
|positive regulation of epithelial cell proliferation|
|positive regulation of T cell activation|
|cell chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|rhythmic process|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|angiogenesis|
|regulation of epithelial cell proliferation|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|regulation of hemopoiesis|
|synaptic signaling|
|muscle structure development|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|response to growth factor|
|chemotaxis|
|taxis|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|cell migration|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|localization of cell|
|cell motility|
|cell-cell signaling|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.92|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.8|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.76|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.74|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.74|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18894
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EGR3 Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>