EIF2B1

Entrez Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009].
UniProt Summary: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 314/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	5/28
bone	8/26
breast	18/33
central nervous system	30/56
cervix	3/4
colorectal	8/17
esophagus	5/13
fibroblast	0/1
gastric	8/16
kidney	10/21
liver	9/20
lung	35/75
lymphocyte	7/16
ovary	12/26
pancreas	8/24
peripheral nervous system	3/16
plasma cell	3/15
prostate	0/1
skin	8/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	10/22
urinary tract	4/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.73
Erlotinib 10μM R05 exp216	2.49

eukaryotic translation initiation factor 2B complex
oligodendrocyte development
translation initiation factor activity
oligodendrocyte differentiation
regulation of translational initiation
guanyl-nucleotide exchange factor activity
glial cell development
response to heat
response to glucose
translational initiation
response to hexose
response to monosaccharide
glial cell differentiation
response to carbohydrate
T cell receptor signaling pathway
response to temperature stimulus
gliogenesis
antigen receptor-mediated signaling pathway
regulation of translation
translation
response to peptide hormone
regulation of cellular amide metabolic process
peptide biosynthetic process
immune response-activating cell surface receptor signaling pathway
response to peptide
immune response-regulating cell surface receptor signaling pathway
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
cellular amide metabolic process
positive regulation of immune response
response to hormone
central nervous system development
response to organonitrogen compound
identical protein binding
response to nitrogen compound
regulation of immune response