EIF2B3 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2B3
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2B subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8891|8891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR50|Q9NR50]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTP transf 3|
|NTP transferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 2B complex|
|nucleotidyltransferase activity|
|translation factor activity, RNA binding|
|oligodendrocyte development|
|translation initiation factor activity|
|oligodendrocyte differentiation|
|hippocampus development|
|guanyl-nucleotide exchange factor activity|
|glial cell development|
|response to heat|
|limbic system development|
|response to glucose|
|response to hexose|
|translational initiation|
|response to monosaccharide|
|glial cell differentiation|
|response to carbohydrate|
|pallium development|
|T cell receptor signaling pathway|
|response to temperature stimulus|
|gliogenesis|
|telencephalon development|
|antigen receptor-mediated signaling pathway|
|translation|
|forebrain development|
|response to peptide hormone|
|peptide biosynthetic process|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|amide biosynthetic process|
|peptide metabolic process|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|brain development|
|head development|
|cellular amide metabolic process|
|positive regulation of immune response|
|response to hormone|
|central nervous system development|
|response to organonitrogen compound|
|response to nitrogen compound|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.84|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.76|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.79|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.84|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.15|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.648|
|[[:human genes:a:alg5|ALG5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 686/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|24/26|
|breast|31/33|
|central nervous system|53/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|17/20|
|lung|69/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 439
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2B3 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>