EIF2B3

Entrez Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-1.84
FBS-Wisent 0.1 R07 exp426	1.71
Centrinone 0.5μM R07 exp343	1.75
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.76
Torin1 0.08μM R02 exp82	1.79
CHIR-124 0.04μM R06 exp272	1.84
SNS-032 25μM R07 exp401	2.15
Olaparib 4μM R08 exp512	2.25

Global Fraction of Cell Lines Where Essential: 686/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/28
bone	24/26
breast	31/33
central nervous system	53/56
cervix	3/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	17/20
lung	69/75
lymphocyte	15/16
ovary	23/26
pancreas	22/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	27/29
uterus	4/5

Expression Distribution

Gene	Correlation
HARS	0.648
ALG5	0.401

NTP transf 3
NTP transferase

eukaryotic translation initiation factor 2B complex
nucleotidyltransferase activity
translation factor activity, RNA binding
oligodendrocyte development
translation initiation factor activity
oligodendrocyte differentiation
hippocampus development
guanyl-nucleotide exchange factor activity
glial cell development
response to heat
limbic system development
response to glucose
response to hexose
translational initiation
response to monosaccharide
glial cell differentiation
response to carbohydrate
pallium development
T cell receptor signaling pathway
response to temperature stimulus
gliogenesis
telencephalon development
antigen receptor-mediated signaling pathway
translation
forebrain development
response to peptide hormone
peptide biosynthetic process
immune response-activating cell surface receptor signaling pathway
response to peptide
immune response-regulating cell surface receptor signaling pathway
amide biosynthetic process
peptide metabolic process
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
brain development
head development
cellular amide metabolic process
positive regulation of immune response
response to hormone