EIF2B5 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2B5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2B5
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2B subunit epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8893|8893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13144|Q13144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2B5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2B5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|W2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 2B complex|
|translation initiation factor binding|
|response to lithium ion|
|positive regulation of translational initiation|
|astrocyte development|
|oligodendrocyte development|
|ovarian follicle development|
|translation initiation factor activity|
|astrocyte differentiation|
|oligodendrocyte differentiation|
|regulation of translational initiation|
|hippocampus development|
|female gonad development|
|development of primary female sexual characteristics|
|guanyl-nucleotide exchange factor activity|
|myelination|
|female sex differentiation|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|limbic system development|
|response to heat|
|positive regulation of translation|
|response to glucose|
|translational initiation|
|response to hexose|
|response to monosaccharide|
|positive regulation of cellular amide metabolic process|
|glial cell differentiation|
|response to carbohydrate|
|pallium development|
|T cell receptor signaling pathway|
|response to temperature stimulus|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|telencephalon development|
|response to endoplasmic reticulum stress|
|sex differentiation|
|aging|
|antigen receptor-mediated signaling pathway|
|regulation of translation|
|response to metal ion|
|translation|
|forebrain development|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|reproductive structure development|
|reproductive system development|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to inorganic substance|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|positive regulation of cell death|
|brain development|
|head development|
|cellular amide metabolic process|
|positive regulation of immune response|
|response to hormone|
|central nervous system development|
|response to organonitrogen compound|
|response to nitrogen compound|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.98|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.9|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.75|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.75|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.75|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.76|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.95|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.96|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif2b4|EIF2B4]]|0.415|
|[[:human genes:p:ppp1r15b|PPP1R15B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 81/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|5/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|5/20|
|lung|9/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 801
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2B5 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>