EIF4A2

Entrez Summary: N/A
UniProt Summary: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	1.84
CR131-b 0.005μM R08 exp474	7.88

Helicase C
DEAD

negative regulation of RNA-directed 5-3 RNA polymerase activity
regulation of RNA-directed 5-3 RNA polymerase activity
eukaryotic translation initiation factor 4F complex
cytoplasmic translational initiation
helicase activity
translation initiation factor activity
RNA helicase activity
cytoplasmic stress granule
cytoplasmic translation
regulation of translational initiation
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
translational initiation
ATPase activity
negative regulation of transferase activity
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
perinuclear region of cytoplasm
viral process
symbiotic process
cellular amide metabolic process
negative regulation of catalytic activity
interspecies interaction between organisms
regulation of transferase activity
cellular response to cytokine stimulus
response to cytokine
negative regulation of molecular function
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
RNA binding
organonitrogen compound biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
ATP binding