EIF4H

Entrez Summary: This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
UniProt Summary: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hypoxia 5%O2 R04 exp191	2.28
Bortezomib 0.005μM R00 exp6	5.48

Gene	Correlation
DDX3X	0.455
EIF4B	0.428

RNA strand-exchange activity
eukaryotic translation initiation factor 4F complex assembly
RNA strand annealing activity
formation of translation preinitiation complex
eukaryotic translation initiation factor 4F complex
ribosomal small subunit binding
translation factor activity, RNA binding
cytoplasmic translational initiation
polysome
translation initiation factor activity
cytoplasmic translation
regulation of translational initiation
translational initiation
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
cadherin binding
regulation of translation
translation
developmental growth
growth
regulation of cellular amide metabolic process
peptide biosynthetic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
perinuclear region of cytoplasm
viral process
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
sexual reproduction
cellular protein-containing complex assembly
multi-organism reproductive process
RNA binding
organonitrogen compound biosynthetic process
reproductive process
reproduction
protein-containing complex assembly
cellular nitrogen compound biosynthetic process