EIF5 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF5
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1983|1983]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55010|P55010]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF-5 eIF-2B|
|W2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic initiation factor eIF2 binding|
|GDP-dissociation inhibitor activity|
|formation of translation preinitiation complex|
|formation of cytoplasmic translation initiation complex|
|translation factor activity, RNA binding|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|cytoplasmic translation|
|regulation of translational initiation|
|activation of GTPase activity|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|cadherin binding|
|GTPase activity|
|regulation of translation|
|translation|
|GTP binding|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|positive regulation of GTPase activity|
|ribonucleoprotein complex biogenesis|
|regulation of GTPase activity|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|regulation of hydrolase activity|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.35|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.91|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.84|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.83|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.82|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.8|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.78|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.78|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.77|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.7|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.95|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.03|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.09|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.3|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.58|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF5 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>