EIF5

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-2.35
BS-181 20μM R08 exp461	-2.05
Rotenone 20μM R00 exp34	-1.91
DABN 20μM R00 exp17	-1.84
Rucaparib 6.5μM R08 exp520	-1.83
Aminopterin 0.005μM R07 exp335	-1.82
SB743921 0.001μM R05 exp244	-1.8
Artemisinin 50μM R08 exp450	-1.78
Deferoxamine 11μM R07 exp350	-1.78
Citral 75μM R06 exp275	-1.77
JQ1 0.8μM R08 exp435	-1.73
MK2206 4μM R08 exp504	-1.7
Campthothecin 0.001μM R06 exp270	1.71
SGC0946 7μM R03 exp151	1.8
Nifuroxazide 5μM R03 exp102	1.95
L-74142 5μM R03 exp131	2
MS094 2μM R03 exp136	2.03
Myriocin 25μM R06 exp293	2.09
Nicotinamide Riboside 100μM R03 exp139	2.3
Sucrose 20000μM R06 exp298	2.58
VE-822 0.04μM R06 exp300	2.61

Global Fraction of Cell Lines Where Essential: 728/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	20/20
lung	72/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	5/5

Expression Distribution

eIF-5 eIF-2B
W2

eukaryotic initiation factor eIF2 binding
GDP-dissociation inhibitor activity
formation of translation preinitiation complex
formation of cytoplasmic translation initiation complex
translation factor activity, RNA binding
cytoplasmic translational initiation
translation initiation factor activity
cytoplasmic translation
regulation of translational initiation
activation of GTPase activity
translational initiation
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
cadherin binding
GTPase activity
regulation of translation
translation
GTP binding
regulation of cellular amide metabolic process
peptide biosynthetic process
positive regulation of GTPase activity
ribonucleoprotein complex biogenesis
regulation of GTPase activity
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
positive regulation of hydrolase activity
cellular amide metabolic process
cellular protein-containing complex assembly
regulation of hydrolase activity
RNA binding
organonitrogen compound biosynthetic process
positive regulation of catalytic activity
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
protein-containing complex subunit organization
gene expression