ELAC2 [The Human Chemical-Genetic Interaction Map Project]

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======= ELAC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELAC2
  * **<color #00a2e8>Official Name</color>**: elaC ribonuclease Z 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60528|60528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ52|Q9BQ52]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELAC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELAC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605367|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. {ECO:0000269|PubMed:21593607}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lactamase B|
|Lactamase B 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-specific ribonuclease activity|
|mitochondrial tRNA 3-trailer cleavage, endonucleolytic|
|tRNA 3-trailer cleavage, endonucleolytic|
|endonucleolytic cleavage involved in tRNA processing|
|tRNA 3-trailer cleavage|
|tRNA 3-end processing|
|mitochondrial tRNA processing|
|mitochondrial RNA processing|
|endonuclease activity|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|ncRNA 3-end processing|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA 3-end processing|
|mitochondrial gene expression|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|mitochondrial matrix|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.05|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.74|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps14|MRPS14]]|0.637|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.593|
|[[:human genes:t:tufm|TUFM]]|0.577|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.577|
|[[:human genes:a:atxn10|ATXN10]]|0.561|
|[[:human genes:s:sars2|SARS2]]|0.558|
|[[:human genes:m:mrpl21|MRPL21]]|0.556|
|[[:human genes:m:mrp63|MRP63]]|0.551|
|[[:human genes:m:mrpl23|MRPL23]]|0.543|
|[[:human genes:m:mrps16|MRPS16]]|0.541|
|[[:human genes:t:thg1l|THG1L]]|0.537|
|[[:human genes:d:dpagt1|DPAGT1]]|0.537|
|[[:human genes:d:dap3|DAP3]]|0.535|
|[[:human genes:g:gmppb|GMPPB]]|0.531|
|[[:human genes:m:mrps33|MRPS33]]|0.53|
|[[:human genes:c:cox16|COX16]]|0.53|
|[[:human genes:y:yars2|YARS2]]|0.529|
|[[:human genes:m:mrps6|MRPS6]]|0.528|
|[[:human genes:d:dars2|DARS2]]|0.526|
|[[:human genes:s:slc25a19|SLC25A19]]|0.524|
|[[:human genes:m:mrps18a|MRPS18A]]|0.521|
|[[:human genes:s:slc25a26|SLC25A26]]|0.52|
|[[:human genes:m:mrps34|MRPS34]]|0.519|
|[[:human genes:a:atp5b|ATP5B]]|0.518|
|[[:human genes:t:tars2|TARS2]]|0.518|
|[[:human genes:a:alg13|ALG13]]|0.516|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.514|
|[[:human genes:v:vezt|VEZT]]|0.512|
|[[:human genes:p:pmm2|PMM2]]|0.511|
|[[:human genes:a:adsl|ADSL]]|0.51|
|[[:human genes:u:uhrf1|UHRF1]]|0.51|
|[[:human genes:t:triap1|TRIAP1]]|0.508|
|[[:human genes:a:alg1|ALG1]]|0.508|
|[[:human genes:g:gfm1|GFM1]]|0.508|
|[[:human genes:m:mrps11|MRPS11]]|0.507|
|[[:human genes:m:mrps9|MRPS9]]|0.507|
|[[:human genes:c:c10orf2|C10orf2]]|0.506|
|[[:human genes:a:atp5j|ATP5J]]|0.504|
|[[:human genes:r:rpusd4|RPUSD4]]|0.5|
|[[:human genes:m:mrps26|MRPS26]]|0.498|
|[[:human genes:z:zrsr2|ZRSR2]]|0.497|
|[[:human genes:m:mrpl27|MRPL27]]|0.495|
|[[:human genes:m:mrps2|MRPS2]]|0.493|
|[[:human genes:u:uap1|UAP1]]|0.489|
|[[:human genes:s:selrc1|SELRC1]]|0.489|
|[[:human genes:m:mrpl15|MRPL15]]|0.486|
|[[:human genes:f:fars2|FARS2]]|0.486|
|[[:human genes:p:pars2|PARS2]]|0.484|
|[[:human genes:m:mrpl53|MRPL53]]|0.483|
|[[:human genes:p:ppa2|PPA2]]|0.483|
|[[:human genes:g:gfpt1|GFPT1]]|0.48|
|[[:human genes:t:tefm|TEFM]]|0.48|
|[[:human genes:y:yars|YARS]]|0.478|
|[[:human genes:s:ssb|SSB]]|0.478|
|[[:human genes:t:tti1|TTI1]]|0.478|
|[[:human genes:a:atp5a1|ATP5A1]]|0.477|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.476|
|[[:human genes:t:tamm41|TAMM41]]|0.475|
|[[:human genes:v:vars2|VARS2]]|0.474|
|[[:human genes:h:haus8|HAUS8]]|0.474|
|[[:human genes:r:rpp21|RPP21]]|0.474|
|[[:human genes:a:alg2|ALG2]]|0.473|
|[[:human genes:r:rnmt|RNMT]]|0.472|
|[[:human genes:p:ppcs|PPCS]]|0.471|
|[[:human genes:b:bcs1l|BCS1L]]|0.47|
|[[:human genes:r:rbfa|RBFA]]|0.468|
|[[:human genes:c:chchd4|CHCHD4]]|0.467|
|[[:human genes:n:ndufb3|NDUFB3]]|0.467|
|[[:human genes:m:mrps21|MRPS21]]|0.467|
|[[:human genes:m:mrps5|MRPS5]]|0.463|
|[[:human genes:t:txnl4b|TXNL4B]]|0.463|
|[[:human genes:h:hccs|HCCS]]|0.463|
|[[:human genes:t:tomm22|TOMM22]]|0.462|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.462|
|[[:human genes:r:rars2|RARS2]]|0.462|
|[[:human genes:u:uqcr10|UQCR10]]|0.458|
|[[:human genes:a:atp5c1|ATP5C1]]|0.458|
|[[:human genes:d:dhrsx|DHRSX]]|0.457|
|[[:human genes:n:ndufa3|NDUFA3]]|0.456|
|[[:human genes:g:gatc|GATC]]|0.456|
|[[:human genes:r:rpia|RPIA]]|0.455|
|[[:human genes:n:nars2|NARS2]]|0.454|
|[[:human genes:a:atp5d|ATP5D]]|0.454|
|[[:human genes:r:rpe|RPE]]|0.453|
|[[:human genes:t:ttc4|TTC4]]|0.452|
|[[:human genes:r:rtcb|RTCB]]|0.452|
|[[:human genes:m:mrpl12|MRPL12]]|0.452|
|[[:human genes:m:mapk14|MAPK14]]|0.451|
|[[:human genes:s:sco2|SCO2]]|0.451|
|[[:human genes:f:fh|FH]]|0.45|
|[[:human genes:a:atp5o|ATP5O]]|0.45|
|[[:human genes:m:mrpl47|MRPL47]]|0.448|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.447|
|[[:human genes:a:aifm1|AIFM1]]|0.447|
|[[:human genes:w:wbscr16|WBSCR16]]|0.443|
|[[:human genes:g:gemin7|GEMIN7]]|0.441|
|[[:human genes:h:hars2|HARS2]]|0.44|
|[[:human genes:l:lsm11|LSM11]]|0.44|
|[[:human genes:m:mrpl34|MRPL34]]|0.439|
|[[:human genes:c:cox5a|COX5A]]|0.439|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.439|
|[[:human genes:g:gfer|GFER]]|0.439|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.438|
|[[:human genes:d:dolk|DOLK]]|0.437|
|[[:human genes:n:ndufb11|NDUFB11]]|0.437|
|[[:human genes:l:lars2|LARS2]]|0.436|
|[[:human genes:m:mrpl44|MRPL44]]|0.435|
|[[:human genes:t:tomm20|TOMM20]]|0.435|
|[[:human genes:a:alg6|ALG6]]|0.433|
|[[:human genes:m:mtg2|MTG2]]|0.433|
|[[:human genes:q:qrsl1|QRSL1]]|0.432|
|[[:human genes:c:c17orf89|C17orf89]]|0.431|
|[[:human genes:d:dhps|DHPS]]|0.431|
|[[:human genes:n:ndufb6|NDUFB6]]|0.429|
|[[:human genes:t:telo2|TELO2]]|0.429|
|[[:human genes:r:rfk|RFK]]|0.428|
|[[:human genes:g:gnb1l|GNB1L]]|0.427|
|[[:human genes:t:tpk1|TPK1]]|0.426|
|[[:human genes:e:eif3f|EIF3F]]|0.426|
|[[:human genes:m:mrpl33|MRPL33]]|0.426|
|[[:human genes:m:mbtps2|MBTPS2]]|0.426|
|[[:human genes:t:ten1|TEN1]]|0.425|
|[[:human genes:m:med4|MED4]]|0.423|
|[[:human genes:a:alg5|ALG5]]|0.423|
|[[:human genes:g:gemin6|GEMIN6]]|0.423|
|[[:human genes:o:osgep|OSGEP]]|0.423|
|[[:human genes:r:rft1|RFT1]]|0.422|
|[[:human genes:t:tprkb|TPRKB]]|0.422|
|[[:human genes:d:ddx20|DDX20]]|0.422|
|[[:human genes:m:mrps25|MRPS25]]|0.422|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.421|
|[[:human genes:t:trmt5|TRMT5]]|0.42|
|[[:human genes:c:c12orf65|C12orf65]]|0.42|
|[[:human genes:f:fastkd5|FASTKD5]]|0.418|
|[[:human genes:p:pdss1|PDSS1]]|0.418|
|[[:human genes:c:cox7b|COX7B]]|0.418|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.417|
|[[:human genes:a:atic|ATIC]]|0.416|
|[[:human genes:m:mars2|MARS2]]|0.416|
|[[:human genes:r:rptor|RPTOR]]|0.416|
|[[:human genes:t:tmem242|TMEM242]]|0.415|
|[[:human genes:d:dohh|DOHH]]|0.415|
|[[:human genes:m:med16|MED16]]|0.414|
|[[:human genes:t:tmem126b|TMEM126B]]|0.413|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.413|
|[[:human genes:c:cox6c|COX6C]]|0.413|
|[[:human genes:s:sec62|SEC62]]|0.412|
|[[:human genes:s:srp14|SRP14]]|0.412|
|[[:human genes:c:cox17|COX17]]|0.412|
|[[:human genes:m:mrpl32|MRPL32]]|0.411|
|[[:human genes:f:fnta|FNTA]]|0.409|
|[[:human genes:m:mrpl20|MRPL20]]|0.409|
|[[:human genes:t:thoc6|THOC6]]|0.409|
|[[:human genes:g:gfm2|GFM2]]|0.409|
|[[:human genes:e:exoc4|EXOC4]]|0.407|
|[[:human genes:p:pdcd5|PDCD5]]|0.407|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.406|
|[[:human genes:m:mrps23|MRPS23]]|0.406|
|[[:human genes:t:trnt1|TRNT1]]|0.406|
|[[:human genes:n:nbn|NBN]]|0.405|
|[[:human genes:l:lsm10|LSM10]]|0.405|
|[[:human genes:c:cbfb|CBFB]]|0.405|
|[[:human genes:c:cox15|COX15]]|0.404|
|[[:human genes:o:oraov1|ORAOV1]]|0.403|
|[[:human genes:t:tmem41b|TMEM41B]]|0.402|
|[[:human genes:m:mrps24|MRPS24]]|0.401|
|[[:human genes:c:cep57|CEP57]]|0.401|
|[[:human genes:h:hspd1|HSPD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 379/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|9/28|
|bone|16/26|
|breast|21/33|
|central nervous system|32/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|8/21|
|liver|10/20|
|lung|41/75|
|lymphocyte|6/16|
|ovary|13/26|
|pancreas|11/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|7/22|
|urinary tract|15/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELAC2 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>