ELAC2

Gene Information

Official Symbol: ELAC2
Official Name: elaC ribonuclease Z 2
Aliases and Previous Symbols: N/A
Entrez ID: 60528
UniProt: Q9BQ52
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. {ECO:0000269|PubMed:21593607}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
MRPS14	0.637
HSD17B10	0.593
TUFM	0.577
SUPV3L1	0.577
ATXN10	0.561
SARS2	0.558
MRPL21	0.556
MRP63	0.551
MRPL23	0.543
MRPS16	0.541
THG1L	0.537
DPAGT1	0.537
DAP3	0.535
GMPPB	0.531
MRPS33	0.53
COX16	0.53
YARS2	0.529
MRPS6	0.528
DARS2	0.526
SLC25A19	0.524
MRPS18A	0.521
SLC25A26	0.52
MRPS34	0.519
ATP5B	0.518
TARS2	0.518
ALG13	0.516
KIAA0391	0.514
VEZT	0.512
PMM2	0.511
ADSL	0.51
UHRF1	0.51
TRIAP1	0.508
ALG1	0.508
GFM1	0.508
MRPS11	0.507
MRPS9	0.507
C10orf2	0.506
ATP5J	0.504
RPUSD4	0.5
MRPS26	0.498
ZRSR2	0.497
MRPL27	0.495
MRPS2	0.493
UAP1	0.489
SELRC1	0.489
MRPL15	0.486
FARS2	0.486
PARS2	0.484
MRPL53	0.483
PPA2	0.483
GFPT1	0.48
TEFM	0.48
YARS	0.478
SSB	0.478
TTI1	0.478
ATP5A1	0.477
UQCRC2	0.476
TAMM41	0.475
VARS2	0.474
HAUS8	0.474
RPP21	0.474
ALG2	0.473
RNMT	0.472
PPCS	0.471
BCS1L	0.47
RBFA	0.468
CHCHD4	0.467
NDUFB3	0.467
MRPS21	0.467
MRPS5	0.463
TXNL4B	0.463
HCCS	0.463
TOMM22	0.462
RNASEH1	0.462
RARS2	0.462
UQCR10	0.458
ATP5C1	0.458
DHRSX	0.457
NDUFA3	0.456
GATC	0.456
RPIA	0.455
NARS2	0.454
ATP5D	0.454
RPE	0.453
TTC4	0.452
RTCB	0.452
MRPL12	0.452
MAPK14	0.451
SCO2	0.451
FH	0.45
ATP5O	0.45
MRPL47	0.448
GTF3C6	0.447
AIFM1	0.447
WBSCR16	0.443
GEMIN7	0.441
HARS2	0.44
LSM11	0.44
MRPL34	0.439
COX5A	0.439
NDUFAF4	0.439
GFER	0.439
GTF3C3	0.438
DOLK	0.437
NDUFB11	0.437
LARS2	0.436
MRPL44	0.435
TOMM20	0.435
ALG6	0.433
MTG2	0.433
QRSL1	0.432
C17orf89	0.431
DHPS	0.431
NDUFB6	0.429
TELO2	0.429
RFK	0.428
GNB1L	0.427
TPK1	0.426
EIF3F	0.426
MRPL33	0.426
MBTPS2	0.426
TEN1	0.425
MED4	0.423
ALG5	0.423
GEMIN6	0.423
OSGEP	0.423
RFT1	0.422
TPRKB	0.422
DDX20	0.422
MRPS25	0.422
GTF3C4	0.421
TRMT5	0.42
C12orf65	0.42
FASTKD5	0.418
PDSS1	0.418
COX7B	0.418
NDUFAF7	0.417
ATIC	0.416
MARS2	0.416
RPTOR	0.416
TMEM242	0.415
DOHH	0.415
MED16	0.414
TMEM126B	0.413
AASDHPPT	0.413
COX6C	0.413
SEC62	0.412
SRP14	0.412
COX17	0.412
MRPL32	0.411
FNTA	0.409
MRPL20	0.409
THOC6	0.409
GFM2	0.409
EXOC4	0.407
PDCD5	0.407
GTF3C2	0.406
MRPS23	0.406
TRNT1	0.406
NBN	0.405
LSM10	0.405
CBFB	0.405
COX15	0.404
ORAOV1	0.403
TMEM41B	0.402
MRPS24	0.401
CEP57	0.401
HSPD1	0.4

Global Fraction of Cell Lines Where Essential: 379/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	9/28
bone	16/26
breast	21/33
central nervous system	32/56
cervix	2/4
colorectal	10/17
esophagus	6/13
fibroblast	1/1
gastric	10/16
kidney	8/21
liver	10/20
lung	41/75
lymphocyte	6/16
ovary	13/26
pancreas	11/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	0/1
skin	14/24
soft tissue	4/9
thyroid	2/2
upper aerodigestive	7/22
urinary tract	15/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 415
Expression level (log2 read counts): 7.68

Expression Distribution

Screen	Score
HMS-I2 1μM R06 exp286	-2.05
Adefovir 20μM R07 exp332	-1.72
Tanespimycin 14μM R08 exp527	1.74
GSK-J4 1.5μM R08 exp441	1.77

Lactamase B
Lactamase B 2

tRNA-specific ribonuclease activity
mitochondrial tRNA 3-trailer cleavage, endonucleolytic
tRNA 3-trailer cleavage, endonucleolytic
endonucleolytic cleavage involved in tRNA processing
tRNA 3-trailer cleavage
tRNA 3-end processing
mitochondrial tRNA processing
mitochondrial RNA processing
endonuclease activity
mitochondrial RNA metabolic process
mitochondrial nucleoid
ncRNA 3-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA 3-end processing
mitochondrial gene expression
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
mitochondrial matrix
ncRNA processing
ncRNA metabolic process
RNA processing
mitochondrion
RNA binding
RNA metabolic process
gene expression