ELF2 [The Human Chemical-Genetic Interaction Map Project]

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======= ELF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELF2
  * **<color #00a2e8>Official Name</color>**: E74 like ETS transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1998|1998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15723|Q15723]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
|Elf-1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of B cell receptor signaling pathway|
|regulation of antigen receptor-mediated signaling pathway|
|nuclear body|
|sequence-specific DNA binding|
|regulation of immune response|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.79|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.66|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.51|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.51|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.44|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.33|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.32|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.31|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.23|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.1|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.95|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.92|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.86|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.86|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.81|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.81|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.76|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.71|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.98|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.01|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.04|
|[[:results:exp539|42°C R08 exp539]]|2.06|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.07|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.14|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.21|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.25|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.3|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.515|
|[[:human genes:d:dohh|DOHH]]|0.448|
|[[:human genes:m:meaf6|MEAF6]]|0.441|
|[[:human genes:v:vdac2|VDAC2]]|0.44|
|[[:human genes:t:triap1|TRIAP1]]|0.432|
|[[:human genes:b:bak1|BAK1]]|0.432|
|[[:human genes:p:plaa|PLAA]]|0.432|
|[[:human genes:w:wdr24|WDR24]]|0.428|
|[[:human genes:u:uap1|UAP1]]|0.424|
|[[:human genes:c:crls1|CRLS1]]|0.419|
|[[:human genes:s:slc4a7|SLC4A7]]|0.409|
|[[:human genes:t:thoc6|THOC6]]|0.407|
|[[:human genes:z:znf592|ZNF592]]|0.406|
|[[:human genes:m:mllt1|MLLT1]]|0.403|
|[[:human genes:r:rptor|RPTOR]]|0.4|
|[[:human genes:r:rnmt|RNMT]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELF2 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>