ELF2

Entrez Summary: N/A
UniProt Summary: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.79
VER-155008 3.9μM R06 exp301	-2.66
BI-D1870 2μM R04 exp162	-2.51
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.51
Vemurafenib 6.6μM R08 exp434	-2.44
Oligomycin-A 2μM R00 exp25	-2.33
Golgicide-A 4μM R03 exp122	-2.32
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.31
THZ531 0.11μM R07 exp409	-2.23
Trimetrexate 0.03μM R08 exp535	-2.1
Beta-Estradiol 0.55μM R07 exp425	-2
BI-2536 0.0042μM R03 exp95	-1.95
BI-D1870 3.15μM R02 exp66	-1.92
Citral 75μM R06 exp275	-1.86
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.86
Q15 2.7μM R02 exp79	-1.82
Colchicine 0.009μM R05 exp215	-1.81
Sucrose 20000μM R06 exp298	-1.81
Momordin-Ic 10μM R08 exp506	-1.76
5-Fluorouracil 2μM R00 exp1	-1.71
UM131593 0.2μM R03 exp106	1.98
JQ1 0.8μM R08 exp435	2.01
5-Fluorouracil 20μM R00 exp2	2.04
42°C R08 exp539	2.06
Actinomycin-D 0.001μM R00 exp3	2.07
Atovaquone 15μM R08 exp451	2.14
AICAR 240μM R05 exp211	2.21
CR131-b 0.005μM R08 exp474	2.25
ML-792 0.2μM R08 exp505	2.3
Tubacin 1.6μM R07 exp416	2.8
GSK626616 14μM R08 exp485	3.69

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ets
Elf-1 N

regulation of B cell receptor signaling pathway
regulation of antigen receptor-mediated signaling pathway
nuclear body
sequence-specific DNA binding
regulation of immune response
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process