ELFN1

Official Symbol: ELFN1
Official Name: extracellular leucine rich repeat and fibronectin type III domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 392617
UniProt: P0C7U0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

excitatory synapse
protein phosphatase inhibitor activity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
extracellular matrix
synapse organization
dendrite
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process