ELL [The Human Chemical-Genetic Interaction Map Project]

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======= ELL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELL
  * **<color #00a2e8>Official Name</color>**: elongation factor for RNA polymerase II
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8178|8178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55199|P55199]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600284|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Occludin ELL|
|ELL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone locus body|
|snRNA transcription by RNA polymerase III|
|positive regulation of transcription by RNA polymerase III|
|positive regulation of transcription elongation from RNA polymerase II promoter|
|regulation of transcription by RNA polymerase III|
|transcriptionally active chromatin|
|transcription elongation factor complex|
|regulation of transcription elongation from RNA polymerase II promoter|
|positive regulation of DNA-templated transcription, elongation|
|transcription by RNA polymerase III|
|phosphatase binding|
|regulation of DNA-templated transcription, elongation|
|Cajal body|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|in utero embryonic development|
|nuclear speck|
|negative regulation of hydrolase activity|
|transcription by RNA polymerase II|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|negative regulation of catalytic activity|
|embryo development|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.72|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.73|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.75|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.78|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.96|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pan3|PAN3]]|0.422|
|[[:human genes:p:polr2j3|POLR2J3]]|0.422|
|[[:human genes:a:atxn1|ATXN1]]|0.414|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:s:smg7|SMG7]]|0.405|
|[[:human genes:m:med17|MED17]]|0.405|
|[[:human genes:p:psmc2|PSMC2]]|0.403|
|[[:human genes:c:copa|COPA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 557/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|21/28|
|bone|20/25|
|breast|21/33|
|central nervous system|32/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|13/15|
|kidney|17/21|
|liver|11/20|
|lung|58/75|
|lymphocyte|9/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 301
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELL Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>