ELL

Gene Information

Official Symbol: ELL
Official Name: elongation factor for RNA polymerase II
Aliases and Previous Symbols: N/A
Entrez ID: 8178
UniProt: P55199
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 7μM R08 exp436	1.7
Quercetin 20μM R08 exp517	1.72
Bisphenol S 100μM R08 exp458	1.73
Dorsomorphin 5μM R07 exp357	1.75
Myriocin 25μM R06 exp293	1.78
Cabazitaxel 0.001μM R05 exp223	1.82
UM131593 0.1μM R01 exp58	1.91
UMK57 1μM R01 exp59	1.96
Thioridazine 5μM R08 exp530	2.04
I-BRD9 4μM R07 exp365	2.29

Global Fraction of Cell Lines Where Essential: 557/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	21/28
bone	20/25
breast	21/33
central nervous system	32/56
cervix	3/4
colorectal	15/17
esophagus	8/13
fibroblast	0/1
gastric	13/15
kidney	17/21
liver	11/20
lung	58/75
lymphocyte	9/14
ovary	25/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	10/15
prostate	1/1
skin	17/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	15/22
urinary tract	25/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 301
Expression level (log2 read counts): 4.81

Expression Distribution

Gene	Correlation
PAN3	0.422
POLR2J3	0.422
ATXN1	0.414
TCEB3CL2	0.409
SMG7	0.405
MED17	0.405
PSMC2	0.403
COPA	0.4

histone locus body
snRNA transcription by RNA polymerase III
positive regulation of transcription by RNA polymerase III
positive regulation of transcription elongation from RNA polymerase II promoter
regulation of transcription by RNA polymerase III
transcriptionally active chromatin
transcription elongation factor complex
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
transcription by RNA polymerase III
phosphatase binding
regulation of DNA-templated transcription, elongation
Cajal body
snRNA transcription by RNA polymerase II
snRNA transcription
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
ncRNA transcription
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
in utero embryonic development
nuclear speck
negative regulation of hydrolase activity
transcription by RNA polymerase II
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
negative regulation of catalytic activity
embryo development
nucleobase-containing compound biosynthetic process
negative regulation of molecular function
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II