ELMO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ELMO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELMO1
  * **<color #00a2e8>Official Name</color>**: engulfment and cell motility 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9844|9844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92556|Q92556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELMO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELMO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELMO CED12|
|DUF3361|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|guanyl-nucleotide exchange factor complex|
|Rac protein signal transduction|
|regulation of defense response to virus by virus|
|vascular endothelial growth factor receptor signaling pathway|
|guanyl-nucleotide exchange factor activity|
|phagocytosis, engulfment|
|SH3 domain binding|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|plasma membrane invagination|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|membrane invagination|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|phagocytosis|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|endocytosis|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|activation of immune response|
|import into cell|
|viral process|
|enzyme linked receptor protein signaling pathway|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|positive regulation of immune response|
|apoptotic process|
|cell migration|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|immune effector process|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|locomotion|
|movement of cell or subcellular component|
|regulation of immune system process|
|intracellular signal transduction|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.86|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.88|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.25|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.3|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.33|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.42|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.66|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELMO1 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>