ELN

Entrez Summary: This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

elastic fiber
extracellular matrix constituent conferring elasticity
contractile actin filament bundle assembly
stress fiber assembly
aortic valve morphogenesis
extracellular matrix binding
aortic valve development
semi-lunar valve development
respiratory gaseous exchange by respiratory system
heart valve morphogenesis
heart valve development
actin filament bundle assembly
actin filament bundle organization
outflow tract morphogenesis
actomyosin structure organization
skeletal muscle tissue development
extracellular matrix structural constituent
regulation of smooth muscle cell proliferation
skeletal muscle organ development
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
extracellular matrix
actin filament organization
heart morphogenesis
regulation of actin filament organization
striated muscle tissue development
muscle organ development
muscle tissue development
extracellular matrix organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
collagen-containing extracellular matrix
regulation of cellular component size
extracellular structure organization
regulation of actin filament-based process
blood circulation
circulatory system process
regulation of protein complex assembly