ELP3 [The Human Chemical-Genetic Interaction Map Project]

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======= ELP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELP3
  * **<color #00a2e8>Official Name</color>**: elongator acetyltransferase complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55140|55140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9T3|Q9H9T3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612722|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation. {ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:15902492, ECO:0000269|PubMed:16713582, ECO:0000269|PubMed:19185337}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Radical SAM|
|Acetyltransf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation|
|phosphorylase kinase regulator activity|
|Elongator holoenzyme complex|
|iron-sulfur cluster binding|
|tRNA wobble uridine modification|
|acetyltransferase activity|
|tRNA wobble base modification|
|transcription elongation factor complex|
|RNA polymerase II complex binding|
|histone acetyltransferase activity|
|transcription elongation from RNA polymerase II promoter|
|tRNA modification|
|DNA-templated transcription, elongation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|neuron migration|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|tRNA processing|
|protein acetylation|
|RNA modification|
|tRNA metabolic process|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|regulation of protein kinase activity|
|regulation of cell migration|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|peptidyl-amino acid modification|
|regulation of cell motility|
|cell migration|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|chromosome organization|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.2|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.01|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.93|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.91|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.86|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.8|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.73|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.71|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.77|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.87|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.02|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.05|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.06|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.16|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.25|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.31|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.39|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.52|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.86|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.91|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.11|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.14|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.67|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:urm1|URM1]]|0.768|
|[[:human genes:e:elp2|ELP2]]|0.735|
|[[:human genes:e:elp6|ELP6]]|0.734|
|[[:human genes:m:mocs3|MOCS3]]|0.696|
|[[:human genes:c:ctu1|CTU1]]|0.693|
|[[:human genes:k:kti12|KTI12]]|0.681|
|[[:human genes:d:dph3|DPH3]]|0.67|
|[[:human genes:c:ctu2|CTU2]]|0.667|
|[[:human genes:e:elp4|ELP4]]|0.606|
|[[:human genes:t:thg1l|THG1L]]|0.59|
|[[:human genes:i:ikbkap|IKBKAP]]|0.58|
|[[:human genes:e:elp5|ELP5]]|0.557|
|[[:human genes:d:dohh|DOHH]]|0.542|
|[[:human genes:r:rpp21|RPP21]]|0.536|
|[[:human genes:t:tkt|TKT]]|0.525|
|[[:human genes:k:kdsr|KDSR]]|0.524|
|[[:human genes:a:atic|ATIC]]|0.52|
|[[:human genes:r:rtcb|RTCB]]|0.512|
|[[:human genes:u:ube2g2|UBE2G2]]|0.502|
|[[:human genes:s:srp14|SRP14]]|0.494|
|[[:human genes:t:tsen54|TSEN54]]|0.492|
|[[:human genes:c:c15orf41|C15orf41]]|0.488|
|[[:human genes:d:ddx1|DDX1]]|0.486|
|[[:human genes:e:exoc4|EXOC4]]|0.484|
|[[:human genes:a:atxn10|ATXN10]]|0.483|
|[[:human genes:a:alg1|ALG1]]|0.483|
|[[:human genes:r:rpe|RPE]]|0.48|
|[[:human genes:t:tubd1|TUBD1]]|0.479|
|[[:human genes:d:dhrsx|DHRSX]]|0.478|
|[[:human genes:s:ssb|SSB]]|0.477|
|[[:human genes:d:dpagt1|DPAGT1]]|0.477|
|[[:human genes:v:vezt|VEZT]]|0.475|
|[[:human genes:d:dolk|DOLK]]|0.467|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.467|
|[[:human genes:n:n6amt1|N6AMT1]]|0.467|
|[[:human genes:p:pdap1|PDAP1]]|0.464|
|[[:human genes:c:c14orf80|C14orf80]]|0.463|
|[[:human genes:d:dr1|DR1]]|0.458|
|[[:human genes:p:pmm2|PMM2]]|0.457|
|[[:human genes:r:rptor|RPTOR]]|0.456|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.455|
|[[:human genes:u:uap1|UAP1]]|0.453|
|[[:human genes:a:adsl|ADSL]]|0.452|
|[[:human genes:t:trmt5|TRMT5]]|0.449|
|[[:human genes:p:pgm3|PGM3]]|0.448|
|[[:human genes:a:alkbh8|ALKBH8]]|0.446|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.445|
|[[:human genes:t:ttc4|TTC4]]|0.445|
|[[:human genes:r:rabggtb|RABGGTB]]|0.444|
|[[:human genes:f:fh|FH]]|0.444|
|[[:human genes:d:dph1|DPH1]]|0.442|
|[[:human genes:g:gfpt1|GFPT1]]|0.437|
|[[:human genes:m:msto1|MSTO1]]|0.437|
|[[:human genes:r:romo1|ROMO1]]|0.436|
|[[:human genes:d:dnlz|DNLZ]]|0.435|
|[[:human genes:u:uba5|UBA5]]|0.431|
|[[:human genes:t:tube1|TUBE1]]|0.43|
|[[:human genes:p:ppp6c|PPP6C]]|0.43|
|[[:human genes:s:slc7a1|SLC7A1]]|0.43|
|[[:human genes:k:kdm8|KDM8]]|0.428|
|[[:human genes:s:slc25a26|SLC25A26]]|0.427|
|[[:human genes:c:casp9|CASP9]]|0.427|
|[[:human genes:r:rft1|RFT1]]|0.423|
|[[:human genes:g:gemin6|GEMIN6]]|0.422|
|[[:human genes:p:ppp4c|PPP4C]]|0.421|
|[[:human genes:e:eef1e1|EEF1E1]]|0.42|
|[[:human genes:a:atp5a1|ATP5A1]]|0.42|
|[[:human genes:l:lsm10|LSM10]]|0.419|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.418|
|[[:human genes:a:atp5o|ATP5O]]|0.418|
|[[:human genes:p:pdcd5|PDCD5]]|0.417|
|[[:human genes:t:triap1|TRIAP1]]|0.417|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.416|
|[[:human genes:o:oraov1|ORAOV1]]|0.415|
|[[:human genes:t:timm22|TIMM22]]|0.415|
|[[:human genes:d:dph5|DPH5]]|0.415|
|[[:human genes:u:utp23|UTP23]]|0.415|
|[[:human genes:s:slc25a19|SLC25A19]]|0.414|
|[[:human genes:z:zrsr2|ZRSR2]]|0.412|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:g:gmppb|GMPPB]]|0.411|
|[[:human genes:s:sec62|SEC62]]|0.411|
|[[:human genes:p:ptar1|PTAR1]]|0.411|
|[[:human genes:r:rnmt|RNMT]]|0.41|
|[[:human genes:f:fam98b|FAM98B]]|0.409|
|[[:human genes:s:srpk1|SRPK1]]|0.409|
|[[:human genes:t:tbcb|TBCB]]|0.409|
|[[:human genes:t:trmt10a|TRMT10A]]|0.407|
|[[:human genes:p:ppcs|PPCS]]|0.406|
|[[:human genes:a:asun|ASUN]]|0.405|
|[[:human genes:a:alg6|ALG6]]|0.405|
|[[:human genes:s:sbds|SBDS]]|0.404|
|[[:human genes:p:pmvk|PMVK]]|0.404|
|[[:human genes:g:gemin8|GEMIN8]]|0.403|
|[[:human genes:c:c7orf26|C7orf26]]|0.403|
|[[:human genes:f:faf2|FAF2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 559/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|17/28|
|bone|21/25|
|breast|22/33|
|central nervous system|46/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|19/21|
|liver|17/20|
|lung|57/75|
|lymphocyte|12/14|
|ovary|22/26|
|pancreas|17/24|
|peripheral nervous system|13/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELP3 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>