ELP3

Entrez Summary: N/A
UniProt Summary: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation. {ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:15902492, ECO:0000269|PubMed:16713582, ECO:0000269|PubMed:19185337}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.2
SGC0946 7μM R03 exp151	-2.01
Erlotinib 10μM R05 exp216	-1.93
Chloroquine 32μM R08 exp470	-1.91
Rapamycin 1μM R00 exp29	-1.86
Vincristine 0.0005μM R04 exp190	-1.8
Dimethyloxaloylglycine 11μM R07 exp314	-1.73
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.71
Latrunculin-B 10μM R07 exp374	1.71
UM0129480 7μM R02 exp85	1.71
Tozasertib 0.1μM R07 exp414	1.77
SNS-032 15μM R08 exp443	1.87
Doxorubicin 0.02μM R08 exp478	2.02
PU-H71 1μM R08 exp515	2.05
CR131-b 0.005μM R08 exp474	2.06
CI-1040 9.5μM R08 exp472	2.16
FK-506 30μM R07 exp359	2.25
Amiloride 100μM R08 exp447	2.31
Cytochalasin-B 5μM R07 exp349	2.39
2-Deoxy-D-glucose 800μM R05 exp214	2.52
MLN-4924 0.2μM R00 exp21	2.75
MS023 2μM R03 exp134	2.86
Artemisinin 50μM R08 exp450	2.91
MS023 7μM R03 exp135	3.11
6-Thio-2-deoxyguanosine 2μM R06 exp259	3.14
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.67
Hippuristanol 0.12μM R08 exp488	4.74

Global Fraction of Cell Lines Where Essential: 559/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	16/28
blood	17/28
bone	21/25
breast	22/33
central nervous system	46/56
cervix	4/4
colorectal	14/17
esophagus	12/13
fibroblast	1/1
gastric	11/15
kidney	19/21
liver	17/20
lung	57/75
lymphocyte	12/14
ovary	22/26
pancreas	17/24
peripheral nervous system	13/16
plasma cell	8/15
prostate	1/1
skin	21/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	27/29
uterus	4/5

Expression Distribution

Radical SAM
Acetyltransf 1

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
phosphorylase kinase regulator activity
Elongator holoenzyme complex
iron-sulfur cluster binding
tRNA wobble uridine modification
acetyltransferase activity
tRNA wobble base modification
transcription elongation factor complex
RNA polymerase II complex binding
histone acetyltransferase activity
transcription elongation from RNA polymerase II promoter
tRNA modification
DNA-templated transcription, elongation
histone acetylation
internal peptidyl-lysine acetylation
neuron migration
peptidyl-lysine acetylation
internal protein amino acid acetylation
tRNA processing
protein acetylation
RNA modification
tRNA metabolic process
protein acylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
regulation of protein kinase activity
regulation of cell migration
nucleolus