EMD

Entrez Summary: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	1.71
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.84
CCCP 0.1μM R00 exp10	2.47

cortical endoplasmic reticulum
mitotic nuclear envelope reassembly
spindle pole centrosome
nuclear envelope reassembly
positive regulation of protein export from nucleus
nuclear outer membrane
negative regulation of fibroblast proliferation
beta-tubulin binding
regulation of protein export from nucleus
nuclear inner membrane
skeletal muscle cell differentiation
nuclear envelope organization
positive regulation of nucleocytoplasmic transport
regulation of fibroblast proliferation
regulation of nucleocytoplasmic transport
spindle
skeletal muscle tissue development
nucleus organization
skeletal muscle organ development
positive regulation of intracellular protein transport
negative regulation of canonical Wnt signaling pathway
nuclear envelope
positive regulation of intracellular transport
negative regulation of Wnt signaling pathway
regulation of intracellular protein transport
nuclear membrane
muscle contraction
actin binding
regulation of canonical Wnt signaling pathway
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
cadherin binding
microtubule
positive regulation of cellular protein localization
regulation of intracellular transport
regulation of Wnt signaling pathway
endomembrane system organization
positive regulation of protein transport