ENHO

Gene Information

Official Symbol: ENHO
Official Name: energy homeostasis associated
Aliases and Previous Symbols: N/A
Entrez ID: 375704
UniProt: Q6UWT2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of glucose homeostasis and lipid metabolism. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10182
Expression level (log2 read counts): -3.7

Expression Distribution

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of transcription regulatory region DNA binding
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
negative regulation of lipid biosynthetic process
regulation of transcription regulatory region DNA binding
positive regulation of Notch signaling pathway
negative regulation of DNA binding
negative regulation of hormone secretion
regulation of insulin receptor signaling pathway
regulation of cellular response to insulin stimulus
negative regulation of lipid metabolic process
hormone activity
regulation of Notch signaling pathway
regulation of DNA binding
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of binding
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
regulation of lipid biosynthetic process
negative regulation of secretion by cell
regulation of peptide hormone secretion
negative regulation of secretion
regulation of hormone secretion
regulation of binding
regulation of lipid metabolic process
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
regulation of hormone levels
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion