ENO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ENO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENO1
  * **<color #00a2e8>Official Name</color>**: enolase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2023|2023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06733|P06733]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Enolase C|
|Enolase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopyruvate hydratase complex|
|phosphopyruvate hydratase activity|
|regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|positive regulation of plasminogen activation|
|negative regulation of cellular response to hypoxia|
|positive regulation of ATP biosynthetic process|
|cell cortex region|
|regulation of cellular response to hypoxia|
|regulation of plasminogen activation|
|regulation of ATP biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|glucose catabolic process to pyruvate|
|NADH regeneration|
|canonical glycolysis|
|M band|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|GTPase binding|
|NADH metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of muscle contraction|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|regulation of protein processing|
|regulation of protein maturation|
|pyruvate metabolic process|
|nucleoside diphosphate metabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|carbohydrate catabolic process|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|positive regulation of small molecule metabolic process|
|hexose metabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of muscle contraction|
|negative regulation of cell growth|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|negative regulation of apoptotic signaling pathway|
|regulation of muscle system process|
|negative regulation of growth|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|response to virus|
|cadherin binding|
|purine ribonucleotide metabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|positive regulation of proteolysis|
|purine-containing compound metabolic process|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|negative regulation of intracellular signal transduction|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|regulation of system process|
|small molecule biosynthetic process|
|cell surface|
|regulation of growth|
|regulation of proteolysis|
|regulation of cellular response to stress|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-3.45|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.91|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.82|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.6|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.5|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.44|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.41|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.41|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.4|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.32|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.27|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-2.18|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.09|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.05|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-2.04|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.04|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.03|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.97|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.95|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.93|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.92|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.92|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.91|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.89|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.88|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.85|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.84|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.84|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.84|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.83|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.8|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.78|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.77|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.76|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.76|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.74|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.73|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.73|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.72|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.72|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.71|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.72|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.79|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.85|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.99|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.23|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.3|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.34|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpe|RPE]]|0.57|
|[[:human genes:h:hars|HARS]]|0.54|
|[[:human genes:t:tpi1|TPI1]]|0.533|
|[[:human genes:p:pgk1|PGK1]]|0.528|
|[[:human genes:p:pkm|PKM]]|0.528|
|[[:human genes:t:triap1|TRIAP1]]|0.518|
|[[:human genes:a:alg1|ALG1]]|0.517|
|[[:human genes:p:pmm2|PMM2]]|0.515|
|[[:human genes:t:thg1l|THG1L]]|0.514|
|[[:human genes:s:srp14|SRP14]]|0.509|
|[[:human genes:n:nsmce1|NSMCE1]]|0.496|
|[[:human genes:d:dpagt1|DPAGT1]]|0.494|
|[[:human genes:d:ddx20|DDX20]]|0.488|
|[[:human genes:s:slc25a26|SLC25A26]]|0.486|
|[[:human genes:g:gemin5|GEMIN5]]|0.48|
|[[:human genes:g:gmppb|GMPPB]]|0.479|
|[[:human genes:c:crls1|CRLS1]]|0.479|
|[[:human genes:t:tkt|TKT]]|0.479|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.478|
|[[:human genes:t:tbca|TBCA]]|0.474|
|[[:human genes:r:rad1|RAD1]]|0.47|
|[[:human genes:u:uhrf1|UHRF1]]|0.47|
|[[:human genes:r:rtcb|RTCB]]|0.47|
|[[:human genes:g:gfpt1|GFPT1]]|0.465|
|[[:human genes:g:gemin8|GEMIN8]]|0.465|
|[[:human genes:m:mars|MARS]]|0.463|
|[[:human genes:r:rnmt|RNMT]]|0.454|
|[[:human genes:c:cops8|COPS8]]|0.45|
|[[:human genes:r:rptor|RPTOR]]|0.447|
|[[:human genes:a:adsl|ADSL]]|0.445|
|[[:human genes:u:uap1|UAP1]]|0.444|
|[[:human genes:t:tgs1|TGS1]]|0.441|
|[[:human genes:m:meaf6|MEAF6]]|0.44|
|[[:human genes:d:dohh|DOHH]]|0.44|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.438|
|[[:human genes:d:ddx55|DDX55]]|0.437|
|[[:human genes:c:cmtr1|CMTR1]]|0.435|
|[[:human genes:n:nae1|NAE1]]|0.434|
|[[:human genes:c:csnk2b|CSNK2B]]|0.432|
|[[:human genes:c:cct7|CCT7]]|0.431|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.429|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.426|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.425|
|[[:human genes:r:rpia|RPIA]]|0.425|
|[[:human genes:t:thoc3|THOC3]]|0.422|
|[[:human genes:n:naa20|NAA20]]|0.421|
|[[:human genes:r:romo1|ROMO1]]|0.42|
|[[:human genes:a:aars|AARS]]|0.419|
|[[:human genes:h:hspd1|HSPD1]]|0.418|
|[[:human genes:r:rbmx2|RBMX2]]|0.418|
|[[:human genes:t:tmem41b|TMEM41B]]|0.417|
|[[:human genes:p:plaa|PLAA]]|0.416|
|[[:human genes:u:utp23|UTP23]]|0.416|
|[[:human genes:t:tbp|TBP]]|0.415|
|[[:human genes:c:cmtr2|CMTR2]]|0.414|
|[[:human genes:w:wdr92|WDR92]]|0.413|
|[[:human genes:e:exoc3|EXOC3]]|0.412|
|[[:human genes:t:tamm41|TAMM41]]|0.411|
|[[:human genes:e:eif4e|EIF4E]]|0.411|
|[[:human genes:e:exoc4|EXOC4]]|0.41|
|[[:human genes:z:znhit1|ZNHIT1]]|0.409|
|[[:human genes:t:ten1|TEN1]]|0.409|
|[[:human genes:v:vezt|VEZT]]|0.409|
|[[:human genes:n:n6amt1|N6AMT1]]|0.407|
|[[:human genes:t:taz|TAZ]]|0.405|
|[[:human genes:r:rabggtb|RABGGTB]]|0.403|
|[[:human genes:o:oraov1|ORAOV1]]|0.402|
|[[:human genes:r:rad50|RAD50]]|0.402|
|[[:human genes:p:pik3r4|PIK3R4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 152/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|4/28|
|bone|4/25|
|breast|6/33|
|central nervous system|9/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|4/21|
|liver|4/20|
|lung|18/75|
|lymphocyte|3/14|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENO1 Expression in NALM6 Cells: 9.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>