ENOPH1 [The Human Chemical-Genetic Interaction Map Project]

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======= ENOPH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENOPH1
  * **<color #00a2e8>Official Name</color>**: enolase-phosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58478|58478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHY7|Q9UHY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENOPH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENOPH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene). {ECO:0000255|HAMAP-Rule:MF_03117, ECO:0000269|PubMed:15843022}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|
|acireductone synthase activity|
|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|
|L-methionine salvage from S-adenosylmethionine|
|L-methionine salvage from methylthioadenosine|
|S-adenosylmethionine cycle|
|amino acid salvage|
|L-methionine biosynthetic process|
|L-methionine salvage|
|methionine biosynthetic process|
|methionine metabolic process|
|sulfur amino acid biosynthetic process|
|S-adenosylmethionine metabolic process|
|aspartate family amino acid biosynthetic process|
|cellular metabolic compound salvage|
|sulfur amino acid metabolic process|
|aspartate family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|magnesium ion binding|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|dephosphorylation|
|cellular amino acid metabolic process|
|sulfur compound metabolic process|
|cofactor metabolic process|
|drug metabolic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.627|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENOPH1 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>