ENOPH1

Entrez Summary: N/A
UniProt Summary: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene). {ECO:0000255|HAMAP-Rule:MF_03117, ECO:0000269|PubMed:15843022}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
acireductone synthase activity
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
L-methionine salvage from S-adenosylmethionine
L-methionine salvage from methylthioadenosine
S-adenosylmethionine cycle
amino acid salvage
L-methionine biosynthetic process
L-methionine salvage
methionine biosynthetic process
methionine metabolic process
sulfur amino acid biosynthetic process
S-adenosylmethionine metabolic process
aspartate family amino acid biosynthetic process
cellular metabolic compound salvage
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
magnesium ion binding
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
dephosphorylation
cellular amino acid metabolic process
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process