ENPP3 [The Human Chemical-Genetic Interaction Map Project]

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======= ENPP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENPP3
  * **<color #00a2e8>Official Name</color>**: ectonucleotide pyrophosphatase/phosphodiesterase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5169|5169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14638|O14638]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENPP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENPP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Somatomedin B|
|Phosphodiest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mast cell proliferation|
|basophil activation involved in immune response|
|inorganic diphosphate transport|
|regulation of mast cell proliferation|
|basophil activation|
|phosphodiesterase I activity|
|nucleoside-triphosphate diphosphatase activity|
|NADH pyrophosphatase activity|
|negative regulation of mast cell activation involved in immune response|
|nucleoside triphosphate catabolic process|
|negative regulation of mast cell activation|
|polysaccharide binding|
|regulation of mast cell activation involved in immune response|
|regulation of mast cell activation|
|scavenger receptor activity|
|pyrimidine nucleotide metabolic process|
|nucleoside phosphate catabolic process|
|negative regulation of leukocyte proliferation|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|negative regulation of immune effector process|
|organophosphate catabolic process|
|negative regulation of inflammatory response|
|negative regulation of immune response|
|inorganic anion transport|
|negative regulation of leukocyte activation|
|nucleic acid binding|
|negative regulation of cell activation|
|ATP metabolic process|
|negative regulation of defense response|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|nucleic acid phosphodiester bond hydrolysis|
|apical plasma membrane|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|nucleobase-containing compound catabolic process|
|external side of plasma membrane|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of immune effector process|
|organic cyclic compound catabolic process|
|granulocyte activation|
|myeloid cell activation involved in immune response|
|nucleobase-containing small molecule metabolic process|
|endocytosis|
|anion transport|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|import into cell|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|calcium ion binding|
|regulation of defense response|
|zinc ion binding|
|organophosphate metabolic process|
|leukocyte activation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|ion transport|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENPP3 Expression in NALM6 Cells: 0.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>