ENPP3

Gene Information

Official Symbol: ENPP3
Official Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Aliases and Previous Symbols: N/A
Entrez ID: 5169
UniProt: O14638
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015].
UniProt Summary: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3520
Expression level (log2 read counts): 0.05

Expression Distribution

Somatomedin B
Phosphodiest

negative regulation of mast cell proliferation
basophil activation involved in immune response
inorganic diphosphate transport
regulation of mast cell proliferation
basophil activation
phosphodiesterase I activity
nucleoside-triphosphate diphosphatase activity
NADH pyrophosphatase activity
negative regulation of mast cell activation involved in immune response
nucleoside triphosphate catabolic process
negative regulation of mast cell activation
polysaccharide binding
regulation of mast cell activation involved in immune response
regulation of mast cell activation
scavenger receptor activity
pyrimidine nucleotide metabolic process
nucleoside phosphate catabolic process
negative regulation of leukocyte proliferation
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
negative regulation of immune effector process
organophosphate catabolic process
negative regulation of inflammatory response
negative regulation of immune response
inorganic anion transport
negative regulation of leukocyte activation
nucleic acid binding
negative regulation of cell activation
ATP metabolic process
negative regulation of defense response
positive regulation of immune effector process
regulation of leukocyte proliferation
nucleic acid phosphodiester bond hydrolysis
apical plasma membrane
regulation of inflammatory response
negative regulation of response to external stimulus
nucleobase-containing compound catabolic process
external side of plasma membrane
heterocycle catabolic process