ENPP7 [The Human Chemical-Genetic Interaction Map Project]

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======= ENPP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENPP7
  * **<color #00a2e8>Official Name</color>**: ectonucleotide pyrophosphatase/phosphodiesterase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339221|339221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UWV6|Q6UWV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENPP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENPP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metalloenzyme|
|Phosphodiest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphingomyelin phosphodiesterase activity|
|sphingomyelin catabolic process|
|sphingomyelin metabolic process|
|sphingolipid catabolic process|
|phospholipid catabolic process|
|membrane lipid catabolic process|
|negative regulation of DNA replication|
|microvillus|
|glycosphingolipid metabolic process|
|regulation of DNA replication|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|organophosphate catabolic process|
|sphingolipid metabolic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|lipid catabolic process|
|phospholipid metabolic process|
|negative regulation of cell population proliferation|
|cellular amide metabolic process|
|zinc ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENPP7 Expression in NALM6 Cells: -0.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>