ENPP7

Entrez Summary: The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016].
UniProt Summary: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Metalloenzyme
Phosphodiest

sphingomyelin phosphodiesterase activity
sphingomyelin catabolic process
sphingomyelin metabolic process
sphingolipid catabolic process
phospholipid catabolic process
membrane lipid catabolic process
negative regulation of DNA replication
microvillus
glycosphingolipid metabolic process
regulation of DNA replication
glycolipid metabolic process
liposaccharide metabolic process
organophosphate catabolic process
sphingolipid metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lipid catabolic process
phospholipid metabolic process
negative regulation of cell population proliferation
cellular amide metabolic process
zinc ion binding
organophosphate metabolic process
cellular lipid metabolic process
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
lipid metabolic process
negative regulation of cellular macromolecule biosynthetic process
integral component of plasma membrane
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of cell population proliferation
organic substance catabolic process
cellular catabolic process
membrane