ENTPD1

Entrez Summary: The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dUTP phosphohydrolase activity
GTP phosphohydrolase activity
dGTP phosphohydrolase activity
dATP phosphohydrolase activity
dTTP phosphohydrolase activity
dCTP phosphohydrolase activity
8-oxo-dGTP phosphohydrolase activity
nucleobase-containing small molecule catabolic process
blood coagulation
coagulation
hemostasis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
wound healing
organic cyclic compound catabolic process
regulation of body fluid levels
nucleobase-containing small molecule metabolic process
response to wounding
cell adhesion
biological adhesion
integral component of plasma membrane
ATP binding
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane