ENTPD5

Gene Information

Official Symbol: ENTPD5
Official Name: ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
Aliases and Previous Symbols: N/A
Entrez ID: 957
UniProt: O75356
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269|PubMed:10400613}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10461
Expression level (log2 read counts): 4.96

Expression Distribution

guanosine-diphosphatase activity
uridine-diphosphatase activity
positive regulation of glycolytic process
de novo posttranslational protein folding
de novo protein folding
positive regulation of ATP metabolic process
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
nucleobase-containing small molecule catabolic process
protein N-linked glycosylation
regulation of glycolytic process
positive regulation of carbohydrate metabolic process
regulation of carbohydrate catabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of phosphatidylinositol 3-kinase signaling
regulation of ATP metabolic process
positive regulation of small molecule metabolic process
regulation of generation of precursor metabolites and energy
ATP metabolic process
regulation of carbohydrate metabolic process
protein folding
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
positive regulation of cellular catabolic process
nucleobase-containing compound catabolic process
glycoprotein metabolic process
regulation of small molecule metabolic process
positive regulation of catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
cell population proliferation
carbohydrate derivative biosynthetic process
regulation of cellular catabolic process