ENTPD8

Entrez Summary: N/A
UniProt Summary: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17095758}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dCTP phosphohydrolase activity
dTTP phosphohydrolase activity
GTP phosphohydrolase activity
8-oxo-dGTP phosphohydrolase activity
dATP phosphohydrolase activity
dGTP phosphohydrolase activity
dUTP phosphohydrolase activity
nucleoside-diphosphatase activity
nucleoside-triphosphatase activity
nucleoside diphosphate biosynthetic process
nucleoside monophosphate biosynthetic process
nucleobase-containing small molecule catabolic process
nucleoside monophosphate metabolic process
nucleoside diphosphate metabolic process
nucleoside phosphate biosynthetic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process