EPB41

Entrez Summary: The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein localization to cell cortex
regulation of protein localization to cell cortex
spectrin-associated cytoskeleton
regulation of intestinal absorption
cell cortex region
1-phosphatidylinositol binding
cortical cytoskeleton
spectrin binding
phosphoprotein binding
regulation of digestive system process
cortical actin cytoskeleton organization
cortical cytoskeleton organization
cytoplasmic side of plasma membrane
positive regulation of protein localization to cell periphery
positive regulation of protein binding
structural constituent of cytoskeleton
protein N-terminus binding
regulation of protein localization to cell periphery
actomyosin structure organization
regulation of cell shape
positive regulation of binding
protein C-terminus binding
basolateral plasma membrane
calmodulin binding
regulation of protein binding
regulation of calcium ion transport
postsynaptic density
actin binding
positive regulation of cellular protein localization
regulation of binding
regulation of metal ion transport
regulation of cell morphogenesis
cell division
actin cytoskeleton organization
regulation of cellular protein localization
cell junction
actin filament-based process
regulation of system process
protein-containing complex
regulation of ion transport