EPB41L2

Entrez Summary: N/A
UniProt Summary: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-1.82
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.8
MLN-4924 0.2μM R00 exp21	1.87
Alpha-Amanitin 0.5μM R00 exp5	2.07
Hinokiflavone 12μM R08 exp487	2.42
Arsenate 40μM R06 exp264	5.86

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH domain binding
positive regulation of protein localization to cell cortex
spectrin
regulation of protein localization to cell cortex
cell cortex region
spectrin binding
COP9 signalosome
cortical actin cytoskeleton organization
cortical cytoskeleton organization
positive regulation of protein localization to cell periphery
actomyosin structure organization
regulation of protein localization to cell periphery
structural molecule activity
actin binding
positive regulation of cellular protein localization
focal adhesion
cell division
actin cytoskeleton organization
regulation of cellular protein localization
cell junction
actin filament-based process
regulation of cellular localization
regulation of protein localization
cytoskeleton organization
cell cycle