EPHB6

Entrez Summary: N/A
UniProt Summary: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.02μM R00 exp23	-1.76
ABT-702 5μM R07 exp318	1.71

ephrin receptor activity
transmembrane-ephrin receptor activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor signaling pathway
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
signaling receptor activity
receptor complex
axon guidance
neuron projection guidance
neuron projection
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
peptidyl-amino acid modification
protein phosphorylation
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
phosphorylation
locomotion
integral component of plasma membrane
ATP binding
generation of neurons
movement of cell or subcellular component
neurogenesis
cell development