EPHX2

Entrez Summary: This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
stilbene catabolic process
stilbene metabolic process
olefin metabolic process
epoxide metabolic process
epoxide hydrolase activity
toxic substance binding
lipid phosphatase activity
ether metabolic process
epoxygenase P450 pathway
long-chain fatty acid biosynthetic process
phospholipid dephosphorylation
phosphatase activity
peroxisomal matrix
regulation of cholesterol metabolic process
positive regulation of blood vessel diameter
arachidonic acid metabolic process
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
cholesterol homeostasis
peroxisome organization
sterol homeostasis
unsaturated fatty acid metabolic process
peroxisome
icosanoid metabolic process
reactive oxygen species metabolic process
regulation of steroid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
xenobiotic metabolic process
lipid homeostasis
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
fatty acid derivative metabolic process
vascular process in circulatory system
regulation of blood pressure
monocarboxylic acid biosynthetic process