EPN1 [The Human Chemical-Genetic Interaction Map Project]

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======= EPN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPN1
  * **<color #00a2e8>Official Name</color>**: epsin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29924|29924]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6I3|Q9Y6I3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607262|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269|PubMed:10557078}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ENTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sprouting angiogenesis|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|clathrin-coated pit|
|regulation of sprouting angiogenesis|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|Notch signaling pathway|
|lipid binding|
|female pregnancy|
|multi-multicellular organism process|
|regulation of angiogenesis|
|regulation of vasculature development|
|in utero embryonic development|
|embryonic organ development|
|endocytosis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|import into cell|
|membrane organization|
|negative regulation of developmental process|
|embryo development|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|negative regulation of response to stimulus|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.52|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.41|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.41|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.14|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.87|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.87|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.83|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.82|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.79|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.79|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.74|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.75|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15851
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPN1 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>