EPN1

Entrez Summary: N/A
UniProt Summary: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269|PubMed:10557078}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Parthenolide 2.5μM R05 exp238	-2.52
Bortezomib 0.005μM R00 exp6	-2.41
Methotrexate 0.01μM R08 exp501	-2.41
Cryptotanshinone 12μM R05 exp227	-2.14
2-Deoxy-D-glucose 800μM R05 exp214	-1.87
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.87
Pyridostatin 4μM R05 exp240	-1.83
Citral 75μM R06 exp275	-1.82
Aminopterin 0.005μM R07 exp335	-1.79
LB-100 4.1μM R02 exp72	-1.79
Golgicide-A 4μM R03 exp122	-1.77
I-BRD9 4μM R07 exp365	-1.74
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.73
Hydroxyurea 100μM R07 exp329	-1.7
VER-155008 3.9μM R06 exp301	1.75
iCRT14 30μM R08 exp492	2.17

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of sprouting angiogenesis
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
clathrin-coated pit
regulation of sprouting angiogenesis
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
Notch signaling pathway
lipid binding
female pregnancy
multi-multicellular organism process
regulation of angiogenesis
regulation of vasculature development
in utero embryonic development
embryonic organ development
endocytosis
chordate embryonic development
embryo development ending in birth or egg hatching
import into cell
membrane organization
negative regulation of developmental process
embryo development
multi-organism reproductive process
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
reproductive process
reproduction
negative regulation of response to stimulus
vesicle-mediated transport