EPS15 [The Human Chemical-Genetic Interaction Map Project]

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======= EPS15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPS15
  * **<color #00a2e8>Official Name</color>**: epidermal growth factor receptor pathway substrate 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2060|2060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42566|P42566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPS15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPS15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocytosis involved in viral entry into host cell|
|receptor-mediated endocytosis of virus by host cell|
|postsynaptic neurotransmitter receptor internalization|
|postsynaptic endocytosis|
|neurotransmitter receptor internalization|
|positive regulation of receptor recycling|
|AP-2 adaptor complex|
|Golgi to endosome transport|
|clathrin coat assembly|
|regulation of receptor recycling|
|polyubiquitin modification-dependent protein binding|
|basal plasma membrane|
|neurotransmitter receptor transport|
|endocytic recycling|
|aggresome|
|negative regulation of epidermal growth factor receptor signaling pathway|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|negative regulation of ERBB signaling pathway|
|ciliary membrane|
|clathrin-coated pit|
|transport of virus|
|receptor internalization|
|multi-organism localization|
|multi-organism transport|
|postsynapse|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|viral entry into host cell|
|post-Golgi vesicle-mediated transport|
|entry into host cell|
|entry into host|
|receptor metabolic process|
|vesicle-mediated transport in synapse|
|SH3 domain binding|
|cytosolic transport|
|early endosome membrane|
|interaction with host|
|viral life cycle|
|endosomal transport|
|receptor-mediated endocytosis|
|protein-containing complex localization|
|vesicle organization|
|cadherin binding|
|apical plasma membrane|
|glutamatergic synapse|
|Golgi vesicle transport|
|establishment of protein localization to organelle|
|endocytosis|
|import into cell|
|intracellular membrane-bounded organelle|
|viral process|
|calcium ion binding|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|identical protein binding|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.71|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.76|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.78|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11460
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPS15 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>