EPS15

Entrez Summary: N/A
UniProt Summary: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endocytosis involved in viral entry into host cell
receptor-mediated endocytosis of virus by host cell
postsynaptic neurotransmitter receptor internalization
postsynaptic endocytosis
neurotransmitter receptor internalization
positive regulation of receptor recycling
AP-2 adaptor complex
Golgi to endosome transport
clathrin coat assembly
regulation of receptor recycling
polyubiquitin modification-dependent protein binding
basal plasma membrane
neurotransmitter receptor transport
endocytic recycling
aggresome
negative regulation of epidermal growth factor receptor signaling pathway
regulation of postsynaptic membrane neurotransmitter receptor levels
negative regulation of ERBB signaling pathway
ciliary membrane
clathrin-coated pit
transport of virus
receptor internalization
multi-organism localization
multi-organism transport
postsynapse
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
viral entry into host cell
post-Golgi vesicle-mediated transport
entry into host cell
entry into host
receptor metabolic process
vesicle-mediated transport in synapse
SH3 domain binding
cytosolic transport
early endosome membrane
interaction with host
viral life cycle
endosomal transport
receptor-mediated endocytosis