EPS8L1

Entrez Summary: N/A
UniProt Summary: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PTB
SH3 1

T cell receptor binding
positive regulation of ruffle assembly
Rac guanyl-nucleotide exchange factor activity
regulation of ruffle assembly
Rho guanyl-nucleotide exchange factor activity
Rho protein signal transduction
ruffle membrane
positive regulation of plasma membrane bounded cell projection assembly
regulation of Rho protein signal transduction
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of Ras protein signal transduction
Ras protein signal transduction
actin binding
cadherin binding
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of cell projection organization
positive regulation of cellular component biogenesis
protein-containing complex
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular component biogenesis
positive regulation of cellular component organization
intracellular signal transduction
regulation of intracellular signal transduction