EPS8L2

Entrez Summary: This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008].
UniProt Summary: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

stereocilium bundle
positive regulation of ruffle assembly
stereocilium tip
Rac guanyl-nucleotide exchange factor activity
regulation of ruffle assembly
Rho guanyl-nucleotide exchange factor activity
Rho protein signal transduction
ruffle membrane
positive regulation of plasma membrane bounded cell projection assembly
vesicle
regulation of Rho protein signal transduction
sensory perception of sound
sensory perception of mechanical stimulus
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of Ras protein signal transduction
Ras protein signal transduction
actin binding
cadherin binding
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of cell projection organization
positive regulation of cellular component biogenesis
protein-containing complex
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular component biogenesis
sensory perception
positive regulation of cellular component organization
nervous system process
intracellular signal transduction
regulation of intracellular signal transduction
system process