EPT1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= EPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SELENOI
  * **<color #00a2e8>Official Name</color>**: selenoprotein I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85465|85465]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0D9|Q9C0D9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDP-OH P transf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ethanolaminephosphotransferase activity|
|phosphotransferase activity, for other substituted phosphate groups|
|phosphatidylethanolamine biosynthetic process|
|phosphatidylethanolamine metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|lipid metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-3.64|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-3.1|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.1|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.75|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.63|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.17|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.06|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.01|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.99|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.97|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.9|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.79|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.82|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.9|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.93|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.06|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.36|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.52|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.57|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem189|TMEM189]]|0.549|
|[[:human genes:p:pcyt2|PCYT2]]|0.527|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5708
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPT1 Expression in NALM6 Cells: 8.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>