EPT1

Entrez Summary: N/A
UniProt Summary: Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-3.64
Cannabidiol 20μM R08 exp466	-3.1
Vemurafenib 6.6μM R02 exp89	-3.1
Q15 1 to 2μM on day4 R04 exp164	-2.75
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.63
Isoniazid 100μM R08 exp494	-2.2
UM0125461 0.74μM R02 exp84	-2.17
GSK2606414 1μM R05 exp236	-2.06
Tubacin 1.6μM R07 exp416	-2.01
WNT3A 44ng/ml R08 exp537	-1.99
Dynasore 7μM R08 exp436	-1.97
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.9
Vemurafenib 6.6μM R08 exp434	-1.79
Dimethyl-Sulfoxide 1pc R03 exp120	1.82
Lead acetate 2000μM R08 exp498 no dilution day6	1.9
LLY-283 2.6μM R06 exp290	1.93
Demecolcine 0.03μM R05 exp228	2.06
JQ1 0.8μM R08 exp435	2.36
Colchicine 0.009μM R05 exp215	2.52
Vitamin-D3 40μM R08 exp536	2.57
RK-33 8μM R08 exp518	2.67

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
TMEM189	0.549
PCYT2	0.527

ethanolaminephosphotransferase activity
phosphotransferase activity, for other substituted phosphate groups
phosphatidylethanolamine biosynthetic process
phosphatidylethanolamine metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
Golgi apparatus
lipid metabolic process