ERAP2
Gene Information
- Official Symbol: ERAP2
- Official Name: endoplasmic reticulum aminopeptidase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 64167
- UniProt: Q6P179
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016].
- UniProt Summary: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13812
- Expression level (log2 read counts): 7.61
ERAP2 Expression in NALM6 Cells: 7.61
