ERBB2IP

Gene Information

Official Symbol: ERBIN
Official Name: erbb2 interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 55914
UniProt: Q96RT1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 0.001μM R08 exp429	-1.96
Azithromycin 100μM R08 exp452	-1.81
CR131-b 0.005μM R08 exp474	-1.78
GSK461364A 0.005μM R03 exp125	1.76
MS094 2μM R03 exp136	1.89
proTAME 5μM R04 exp187	1.94
Phenformin 20μM R03 exp143	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12288
Expression level (log2 read counts): 6.76

Expression Distribution

PDZ
LRR 4

basal protein localization
negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
ErbB-2 class receptor binding
negative regulation of monocyte chemotactic protein-1 production
regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
hemidesmosome
regulation of nucleotide-binding oligomerization domain containing signaling pathway
regulation of monocyte chemotactic protein-1 production
negative regulation of chemokine production
response to muramyl dipeptide
ERBB2 signaling pathway
basal plasma membrane
establishment or maintenance of epithelial cell apical/basal polarity
regulation of postsynaptic membrane neurotransmitter receptor levels
intermediate filament cytoskeleton organization
establishment or maintenance of apical/basal cell polarity
establishment or maintenance of bipolar cell polarity
epidermal growth factor receptor signaling pathway
intermediate filament-based process
ERBB signaling pathway
regulation of chemokine production
negative regulation of NF-kappaB transcription factor activity
postsynapse
basement membrane
integrin-mediated signaling pathway
structural constituent of cytoskeleton
negative regulation of DNA-binding transcription factor activity
establishment or maintenance of cell polarity
basolateral plasma membrane
nuclear membrane
cellular response to tumor necrosis factor
response to tumor necrosis factor
negative regulation of cytokine production
response to lipopolysaccharide
response to molecule of bacterial origin
signaling receptor binding
glutamatergic synapse
protein targeting
nuclear speck