ERH

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 731/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	19/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Screen	Score
Rapamycin 1μM R00 exp29	1.75
SGC2096 2.6μM R03 exp153	2.11

methylosome
methyl-CpG binding
pyrimidine nucleoside metabolic process
pyrimidine nucleotide biosynthetic process
positive regulation of Notch signaling pathway
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
regulation of Notch signaling pathway
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
midbody
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
positive regulation of signal transduction
small molecule metabolic process
positive regulation of cell communication
positive regulation of signaling