ERI1

Entrez Summary: N/A
UniProt Summary: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:16912046}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HARS	0.534
TOP2B	0.413

SAP
RNase T

histone pre-mRNA stem-loop binding
DNA catabolic process, exonucleolytic
histone pre-mRNA 3end processing complex
exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
exonucleolytic trimming involved in rRNA processing
rRNA 3-end processing
histone mRNA catabolic process
3-5 exonuclease activity
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
cleavage involved in rRNA processing
maturation of 5.8S rRNA
DNA catabolic process
histone mRNA metabolic process
3-5-exoribonuclease activity
rRNA binding
RNA phosphodiester bond hydrolysis, exonucleolytic
ncRNA 3-end processing
ribosome binding
gene silencing by RNA
RNA 3-end processing
gene silencing
RNA phosphodiester bond hydrolysis
nuclear-transcribed mRNA catabolic process
rRNA processing
mRNA catabolic process
rRNA metabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
nucleobase-containing compound catabolic process
ncRNA processing
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organic cyclic compound catabolic process
mRNA metabolic process
DNA metabolic process
nucleolus