ERLEC1

Gene Information

Official Symbol: ERLEC1
Official Name: endoplasmic reticulum lectin 1
Aliases and Previous Symbols: N/A
Entrez ID: 27248
UniProt: Q96DZ1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011].
UniProt Summary: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18502753}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9440
Expression level (log2 read counts): 5.15

Expression Distribution

negative regulation of retrograde protein transport, ER to cytosol
negative regulation of protein exit from endoplasmic reticulum
negative regulation of ERAD pathway
regulation of retrograde protein transport, ER to cytosol
endoplasmic reticulum to cytosol transport
retrograde protein transport, ER to cytosol
endoplasmic reticulum quality control compartment
protein exit from endoplasmic reticulum
regulation of protein exit from endoplasmic reticulum
regulation of ERAD pathway
negative regulation of intracellular protein transport
negative regulation of response to endoplasmic reticulum stress
negative regulation of proteasomal protein catabolic process
negative regulation of intracellular transport
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
ERAD pathway
negative regulation of cellular protein localization
unfolded protein binding
negative regulation of protein catabolic process
negative regulation of protein transport
regulation of proteasomal protein catabolic process
negative regulation of establishment of protein localization
regulation of proteolysis involved in cellular protein catabolic process
regulation of intracellular protein transport
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
negative regulation of catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of intracellular transport
negative regulation of proteolysis
regulation of protein catabolic process
negative regulation of transport
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process